Antibody Humanization

Updates and Information on Antibody Humanization

Categories

Antibody Discovery VHH Antibody Single B Cell Screening Hybridoma Sequencing Antibody Optimization Affinity Maturation Antibody Humanization Antibody Production HTP Recombinant Antibody Bispecific Antibody Afucosylated Antibody Recombinant Protein Expression Stable Cell Line Antibody Resource Antibody Therapeutics

What is Antibody Humanization?

Learn about antibody humanization, including chimeric antibodies, CDR grafting, and transgenic mice, reducing immunogenicity to enhance therapeutic safety and efficacy.

Sep 17, 2024

Read time: 5 mins

Antibody Humanization

A major challenge associated with the use of murine monoclonal antibodies as a therapeutic is their immunogenicity causing a human anti-mouse antibody (HAMA) response. To tackle this issue, chimeric antibodies were created using genetic engineering techniques, combining human constant domains with mouse variable domains that recognized the human antigen of interest, thus preserving antibody specificity.

Jan 27, 2024

Read time: 3 mins