Antibody Optimization

Learn about antibody structure & function, including the roles of Fab & Fc regions in antigen binding & immune response, key to therapeutic antibody development.

Discover the evolution of engineered antibody formats from monoclonal to bispecific antibodies, highlighting milestones in immunotherapy and clinical applications.

Explore the complex regulation of antibody generation, from Tregs and APCs to mechanisms like somatic hypermutation and V(D)J recombination, ensuring immune precision.

Discover how antibody engineering techniques like humanization, affinity maturation, & bispecific development enhance therapeutic efficacy while reducing immunogenicity.

Explore how deep learning models like DeepH3 & DeepAb predict antibody structures, aiding in the design of high-affinity antibodies by modeling CDR loops & FV regions.

Explore how sequence, structural, therapeutic, and experimental databases revolutionize antibody engineering, enhancing discovery, design, and therapeutic development.

Learn how platforms like AlphaFold2 and IgFold transform antibody research with precise protein structure predictions, boosting antibody-antigen interaction studies.

Learn how antibody fragmentation enhances research & therapy. Explore Fab, scFv & VHH fragments for targeted drug delivery, diagnostics & tissue penetration.

Learn about the HAMA response, its impact on research and therapy, and strategies like humanized antibodies and quality control to minimize immunogenicity risks.

Discover strategies for antibody optimization, including humanization, deimmunization, affinity maturation, & Fc engineering, to improve therapeutic safety and efficacy.