Antibody affinity refers to the strength of the binding interaction between a single antigen epitope and the paratope (binding site) of an antibody. This interaction is a fundamental measure of how well an antibody recognizes its specific antigen target.

Explore innovative strategies for optimizing CDR loops in therapeutic antibodies. Enhance antigen binding and specificity to advance pharmaceutical development.

Discover how somatic hypermutation drives the maturation of therapeutic antibodies, optimizing their properties for improved efficacy and safety in medical applications.

Discover how high-affinity antibodies enhance therapeutic precision, reduce side effects, and improve patient outcomes by targeting disease antigens effectively.

DOI:10.1126/science.adg0564 B cells, or B lymphocytes, are a crucial component of the adaptive immune system andhumoral immunity. They originate from the bone marrow and mature in secondary lymphoid organs, such as the spleen and lymph nodes. The B ce

Discover how antibody engineering techniques like humanization, affinity maturation, & bispecific development enhance therapeutic efficacy while reducing immunogenicity.

Understand affinity maturation, from in vivo somatic hypermutation to in vitro optimization using Biointron’s FCMES-AM™ platform for improved antibody binding.

Discover strategies for antibody optimization, including humanization, deimmunization, affinity maturation, & Fc engineering, to improve therapeutic safety and efficacy.