Discover Fab, F(ab')2, and Fc antibody fragments—how they are formed, their functions in targeting antigens, and their evolution in research and therapy.

The development and approval of novel antibody drugs represent a significant segment of pharmaceutical innovation, addressing a wide range of diseases from cancer to autoimmune disorders. Since the first monoclonal antibody (mAb) drug was approved in 1986, there has been explosive growth in this area. By 2021, the US FDA had approved its 100th mAb product, with mAbs now accounting for nearly a fifth of the agency’s new drug approvals each year.

Explore bispecific antibodies: dual-antigen targeting, IgG-like & non-IgG-like formats, innovative design techniques, & transformative applications in cancer immunotherapy.

This week, exciting news came out that Eledon Pharmaceuticals’ tegoprubart was successfully used to aid the first-ever transplant of a genetically-edited pig kidney into a 62-year-old man with end-stage kidney disease. Tegoprubart is an investigational anti-CD40L antibody that has a high affinity for CD40 ligand. CD40L signaling plays an important role in adaptive and innate immune cell activation and function, and is therefore a target for non-lymphocyte depleting, immunomodulatory therapeutic intervention.

Discover how antibody engineering techniques like humanization, affinity maturation, & bispecific development enhance therapeutic efficacy while reducing immunogenicity.

Discover how Contract Research Organizations (CROs) streamline therapeutic development through expertise, cost-effectiveness, and scalability, driving innovation in biotech and pharma.

Learn how single B cell antibody technology accelerates antibody discovery with faster timelines, natural VH-VL pairing, & high-throughput screening for therapeutic innovation.

Image credit: DOI: 10.3390/cancers16040800 In recent decades, the landscape of therapeutic antibodies has undergone a rapid evolution, catalyzing breakthroughs in modern medicine. These antibodies, characterized by their precise targeting and minimal side effects

The nucleocapsid of a virus, which consists of the capsid enclosing the viral nucleic acid, can be a target for antibody therapies. When a virus infects a host, its nucleocapsid becomes exposed to the immune system, triggering the production of antibodies specific to proteins present on the nucleocapsid's surface, preventing the virus from entering host cells, disrupting its replication cycle, or marking it for destruction by other components of the immune system.

In the realm of combating bacterial infections and antimicrobial resistance, antibodies are beginning to stand out as a therapy with innovative strategies and engineering methods continually being published. This month’s trend will focus on the developments in ‘antibiotic antibodies’, antibody-antibiotic conjugates, and antibody antimicrobials, which are particularly important for immunocompromised patients.

Explore agonist antibodies: their mechanisms, role in activating receptors like CD40, immune modulation, & potential in cancer & autoimmune therapy.

Toxins are substances produced by living organisms, such as bacteria, fungi, plants, and animals, that are harmful to other organisms. Antibodies play a crucial role in immune responses for the body's defense against toxin intoxication, in addition to being invaluable tools for both diagnostic and therapeutic applications.

Learn how recombinant antibody production uses genetic engineering to produce highly specific antibodies, bypassing traditional methods for diverse therapeutic & diagnostic applications.

Examine how CHO cell line development and optimized upstream processing drive therapeutic antibody production, ensuring high yields and therapeutic efficacy.

Discover the methods like ELISA, SPR, and AI-driven high-throughput screening used to identify therapeutic antibodies, ensuring specificity, safety, and efficacy.