Antibodies with high purity and low endotoxin levels!
Knocked out Fut8 cell line is applied in producing afucosylated antibodies. Fut8 is an enzyme
that catalyzes the formation of a-1,6 fucosyl glycosidic bonds, and thus the addition of fucose
to asparagine-linked N-acetylglucosamine moieties.1
Biointron's fucose-free host cell CHOK1BN-Fut8KO can be used for
industrial production after antibody characterization and functional verification. Compared to
the unmodified CHOK1BN cell line, the antibody produced by the
modified cell line not only achieves afucosylation but also maintains consistency in terms of
expression quantity and quality.
