Chimeric antibodies, formed by combining the variable regions of one species with the constant domains of another, are essential for various research fields, especially in vivo and in vitro studies. These hybrid antibodies maintain their antigen-binding specificity while offering flexibility in different research settings. This flexibility makes them highly valuable for biotherapeutic research, immunoassays, and diagnostic applications.

The development of chimeric antibodies was a significant turning point in antibody engineering. To engineer more human-like antibodies, researchers combined the variable regions of antibodies from one species with the constant regions of another, resulting in increased antigen specificity with reduced immunogenicity. This was a key advance in making antibodies more suitable for therapeutic applications in humans.

Explore antibody engineering techniques like phage display, humanization, and computational design, enabling the development of safer and more effective therapeutic antibodies.