Immunoglobulin Fc receptors (FcRs) are membrane molecules expressed by several hematopoietic cells that connect antibody-mediated recognition of pathogens with cellular responses. FcRs recognize the Fc region (constant portion) of antibodies, facilitating the immune response against infections and other threats.

Discover the critical role of FcRn in IgG recycling, maternal antibody transfer, and its impact on therapeutic antibody development for enhanced longevity and efficacy.

Immune checkpoint blockade antibody therapy is an approach in cancer treatment that uses the body's immune system to target and destroy cancer cells. Immune checkpoints are regulatory pathways in immune cells that cancer cells exploit to evade detection. Key immune checkpoints include PD-1, PD-L1, and CTLA-4. By blocking these pathways, antibodies like pembrolizumab, nivolumab, and ipilimumab allow T-cells to recognize and attack cancer cells more effectively.

Fc-mediated antibody effector functions play an important role in the humoral immune response and form a necessary link between innate and adaptive immunity. The constant (Fc) region is the tail portion of an antibody that interacts with other components of the immune system, such as immune cells and complement proteins. Well-known functions include opsonization, antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement activation.

The 4th Fc-Mediated Function Summit 2024 was held in Boston, MA from April 17-18, and focused on discussions supercharging FcRn, FcγR, and IgG to advance molecular development, clinical utility, and novel therapeutic applications.

Discover Fab, F(ab')2, and Fc antibody fragments—how they are formed, their functions in targeting antigens, and their evolution in research and therapy.

Biointron is thrilled to be part of the 4th Fc-Mediated Function Summit, a pivotal event focusing on the latest developments in FcRn, FcγR, and IgG, aiming to enhance related therapeutic applications. This unique conference, happening in Boston from April 16-18, 2024, will be gathering over 80 specialists in the field to share insights on molecular engineering and clinical outcomes.