As antibody-based therapies continue to advance the treatment of cancer, autoimmune diseases, and infectious disorders, a parallel challenge has emerged: managing the immune system’s response to these biologics.
Patients with ovarian cancer are often diagnosed late and prone to frequent relapse. Despite advances in surgery and chemotherapy, treatment resistance can leave clinicians with limited options. But a new generation of antibody-based therapies is offering renewed hope, combining precision targeting with immune activation and potent cytotoxic delivery.
Just this week, Merida Biosciences emerged from stealth with a $121 million Series A financing to develop a new class of precision therapeutics that eliminate pathogenic antibodies in autoimmune and allergic diseases. With programs targeting Graves’ disease, primary membranous nephropathy, and seve
Affinity maturation is a fundamental process in the adaptive immune response that results in the selection of B cells producing antibodies with increased binding affinity for their target antigen. This process occurs in germinal centers and is driven by somatic hypermutation and selection pressures.
The therapeutic potential of monoclonal antibodies (mAbs) has expanded dramatically over the past two decades, driven not only by advances in target discovery but also by innovations in antibody engineering. Among these, the engineering of the fragment crystallizable (Fc) domain has emerged as a pow
Biointron’s Q1 2025 annual antibody report aims to explore the events and trends of the biopharmaceutical industry in 2025 (January, February, March).
Affinity maturation is a fundamental process in adaptive immunity, enabling B cells to refine antibody specificity and enhance binding strength through iterative cycles of somatic hypermutation (SHM) and selection. This natural optimization mechanism is not only crucial for effective immune response
G protein-coupled receptors (GPCRs) and ion channels are protein families linked to a broad spectrum of diseases, known as GPCR- and ion channel-driven diseases, which arise from dysfunction in cell signaling and ion transport. GPCR-driven diseases include conditions such as cancer, metabolic disord
Six years after the emergence of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), the landscape of viral neutralization has shifted significantly. Advances in antibody therapeutics, vaccine development, and immune response understanding have reshaped our approach to combating COVID-19 a
Immunotoxins are a class of targeted therapies that consist of an antibody conjugated to a potent toxin, designed to selectively deliver the toxin to cancer cells. Unlike antibody-drug conjugates (ADCs), which use a cytotoxic payload, immunotoxins leverage bacterial or plant-derived toxins, such as Pseudomonas exotoxin A (PE), diphtheria toxin, ricin, or gelonin, to kill cancer cells directly.
Amyloidosis is a rare disease characterized by the abnormal accumulation of misfolded proteins called amyloids in various organs and tissues, leading to organ dysfunction. These protein deposits can affect the heart, kidneys, liver, nervous system, and other areas, causing symptoms such as fatigue, swelling, numbness, and organ failure.
Antibody-toxin conjugates (ATCs) are targeted therapeutic agents that combine an antibody with a potent toxin to selectively eliminate diseased cells, such as cancer cells or infected cells. These conjugates leverage the antibody’s specificity to deliver the toxin directly to target cells, minimizi
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