In the current competitive biotherapeutic market, predominantly driven by antibody molecules, bispecific antibodies represent a key component of the next generation of antibody therapy. Immunoglobulin G (IgG), the most common type of antibody found in blood circulation, are monospecific and recognize only a single antigen, with the exception of IgG4. In contrast, bispecific antibodies are designed to recognize and bind to two different targets.
This is useful as a therapeutic as they can be designed to redirect, for instance, immune cells such as T cells, to selectively engage and eliminate target tumor cells, by allowing effective binding of tumor cell receptors while also recruiting cytotoxic immune cells. In addition, bispecific antibodies can assist in the delivery of therapeutic payloads, such as toxins or drugs, to specific sites in the body.
There are several approaches to producing bispecific antibodies, with the common methods being:
Knobs-in-holes
Ig-scFv fusion
Diabody-Fc fusion
Dual-Variable-Domain-IgG
Biointron has expressed thousands of bispecific antibodies, and we have extensive experience in bispecific antibody production. We take pride in our ability to cater to any client request, offering a wide array of formats in bispecific antibody production.
Abinvivo offers a range of antibody products for in vivo research, each designed to meet specific research needs and applications in preclinical studies and antibody development.
Complementarity-determining regions (CDRs) are polypeptide sequences within antibodies (Abs) that dictate the specific recognition and binding of antigens. Antibodies are part of the human immune response and are composed of two heavy and two light protein chains. These chains are divided into variable (V) and constant (C) regions, with the V region responsible for binding to unique antigens.
Antigens are molecules or molecular structures that are recognized by the immune system, particularly by antibodies, T cells, and B cells. The immune response to an antigen varies depending on the antigen type and the part of the immune system involved. This interaction underpins immunity by helping the body distinguish between self and non-self molecules.