Applications of VHH Antibodies

VHH antibodies, derived from camelid single-domain antibodies, have a small size, high stability, and high binding affinity, making them ideal candidates for a wide range of therapeutic and diagnostic applications.

Jan 20, 2025
The Discovery of VHH Antibodies

VHH antibodies are derived from heavy-chain-only antibodies (HCAbs) found in species like alpacas, camels, and cartilaginous fish. Unlike conventional antibodies, which are composed of both heavy and light chains, HCAbs lack light chains and the CH1 domain, resulting in a single-domain structure known as VHH or nanobody.

Jan 15, 2025
What are VHH Antibodies?

VHHs, also known as single-domain antibodies (sdAbs) or nanobodies, are the smallest antigen-binding fragments derived from heavy-chain-only antibodies found in camelids, such as alpacas, llamas and camels.

Sep 30, 2024
What is Antibody Drug Development?

For more than 30 years, antibody drug development has transformed the landscape of immunotherapy, treating various diseases from cancer to autoimmune diseases. The use of therapeutic monoclonal antibodies (mAbs) began after the groundbreaking development of the hybridoma technique by Kohler and Milstein in 1975, with further development into humanization approaches over the next decade.

Sep 26, 2024
What is a VHH Library?

Learn about VHH libraries, their creation, screening & structural diversity. Discover how nanobody technology advances research, diagnostics & therapeutics.

Sep 23, 2024
What are Innovative Antibody Formats?

Discover innovative antibody formats like VHHs, multispecific antibodies, Fab fragments, scFvs, and ADCs, transforming therapeutic strategies for complex diseases.

Sep 13, 2024
Week 3, August 2024: VHH Antibodies Everywhere

VHH antibodies, also known as nanobodies, are single-domain antibodies that are derived from camelid heavy-chain antibodies. Due to their small size (~ 15 kDa) and diverse applications in bio-derived therapeutics, these antibodies have widespread attention in the research and development community, with some examples below from just this week!

Aug 20, 2024
The Unique Origin of VHH Antibodies: Camelids

Explore VHH antibodies from camelids, their unique structure, evolutionary advantages & applications in diagnostics & therapeutics. Learn why they’re revolutionizing biotech.

Jul 01, 2024
The Promise of VHH Antibodies

Discover the role of VHH antibodies in diagnostics & therapeutics, from viral treatments to precision diagnostics. Learn how they revolutionize antibody-based applications.

Jun 05, 2024
A Historical Overview of VHH Antibodies

Explore an overview of VHH antibodies, from discovery to commercialization. Learn about their unique properties & applications in therapeutics, diagnostics & biotech!

May 04, 2024
Antibody Basics: Part 2​ - Antibody formats: VHHs​

Learn about VHH antibodies, their history, applications in diagnostics and therapeutics, and their role in cutting-edge diagnostics like ELISA and biosensors.

Feb 02, 2024
HTP Recombinant Antibody & VHH Production

Explore HTP recombinant antibody & VHH production for fast, scalable antibody discovery. Learn how Biointron’s high-throughput platform accelerates research & development.

Jan 27, 2024
VHH Library Generation

Explore VHH library generation, from camelid immunization to screening & purification. Learn how Biointron accelerates nanobody discovery for research & therapeutics.

Jan 26, 2024
Antibody Fragmentation

Learn how antibody fragmentation enhances research & therapy. Explore Fab, scFv & VHH fragments for targeted drug delivery, diagnostics & tissue penetration.

Jan 20, 2024
The Ethics of Antibody Production in Animals for Research

Explore the ethical implications of animal-derived antibodies in research, alternatives like in vitro methods, and adherence to 3Rs principles for animal welfare.

Jan 20, 2024

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