VHH Antibodies

Explore VHH-based biosensors for high-sensitivity detection using nanobodies in electrochemical, SPR, and optical diagnostic platforms.

Explore how VHH antibodies stabilize protein conformations for crystallography, cryo-EM, and structural biology applications in protein structure studies.

Explore VHH antibody production strategies for molecular imaging probes, including PET, SPECT, MRI, and optical imaging applications using nanobodies.

Explore VHH intrabodies for intracellular targeting, protein interaction studies, and therapeutic research applications. Learn more with Biointron.

Explore VHH Fc fusion and enzyme strategies to improve antibody half-life, effector functions, and targeted delivery. Learn more with Biointron.

VHH half extension mechanisms like Fc fusion, albumin binding, and PEGylation to improve pharmacokinetics and performance. Contact Biointron.

Learn how multivalent and bispecific VHH antibodies are engineered, their advantages, applications, and key challenges in therapeutic development.

Explore VHH antibody humanization strategies, challenges, and validation methods to reduce immunogenicity while preserving stability and binding.

Antibody affinity is a core metric in immunology and biopharmaceutical science. It refers to the strength of the interaction between a single antigen epitope and the paratope (binding site) of an antibody. In the case of VHH antibodies, also called single-domain antibodies or nanobodies, this interaction occurs through the unique, compact paratope located on their heavy-chain-only variable domain.

VHH antibodies are single-domain antibody fragments derived from the unique heavy-chain-only antibodies (HCAbs) of camelids, including alpacas, llamas, and camels.

Antibody thermal stability refers to the ability of an antibody to retain its structural conformation and binding function when exposed to elevated temperatures. It includes both chemical and physical aspects of protein integrity. Thermal stability is especially critical in therapeutic and diagnostic applications where antibodies must remain effective during manufacturing, shipping, storage, and use.

Discover how immune, naïve and synthetic VHH libraries are built, biopanned and optimized for therapeutic, diagnostic, imaging and research use globally now.